Infertility may develop due to multiple interrelated factors rather than a single cause. Hormonal imbalances, irregular ovulation, poor egg or sperm quality, uterine or tubal issues, thyroid disturbances, and metabolic disorders can interfere with natural conception. Ayurveda emphasizes that weak digestive fire (Agni) leads to toxin accumulation (Ama), which obstructs the reproductive channels (Srotas).